期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 9, 页码 1241-1243出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00186-X
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In our search for M-2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M-2-subtype selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.
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