期刊
BIOCHEMICAL JOURNAL
卷 429, 期 -, 页码 419-433出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20100567
关键词
cell adhesion; desmosome; hyperadhesion; pemphigus; tissue development; tissue remodelling
资金
- Medical Research Council [G0700074, G08000041]
- Wellcome Trust [086167/Z/08/Z]
- Wellcome Trust [086167/Z/08/Z] Funding Source: Wellcome Trust
- MRC [G0700074] Funding Source: UKRI
- Medical Research Council [G0700074] Funding Source: researchfish
Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as how they are assembled and down-regulated. Desmosomal components also have signalling functions that are important in tissue development and remodelling. Their adhesive and signalling functions are both compromised in genetic and autoimmune diseases that affect the heart, skin and mucous membranes. We conclude that much work is required on structure-function relationships within desmosomes in vivo and on how they participate in signalling processes to enhance our knowledge of tissue homoeostasis and human disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据