期刊
BIOCHEMICAL JOURNAL
卷 432, 期 -, 页码 47-55出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20100847
关键词
cartilage; chondroitin sulfate; collagen fibre; N-acetylgalactosaminyltransferase (GalNAcT); gene knockout; glycosaminoglycan
资金
- MEXT (Ministry of Education, Culture, Sports, Science and Technology) of Japan (KAKENHI) [17023019, 22240040, 20570187, 21380025, 21390488, 21249080, 21300118]
- Naito Foundation
- Research and Development Program for New Bio-industry Initiatives
- Niigata University
- TOGONO
- Grants-in-Aid for Scientific Research [21300118, 21380025, 21249080, 20570187, 21390488] Funding Source: KAKEN
CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acetylgalactosaminyltransferase 1)-null mice. CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced. Moreover, the cartilage of the null mice was significantly smaller than that of wild-type mice. Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage.
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