期刊
BIOCHEMICAL JOURNAL
卷 420, 期 -, 页码 1-16出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20090272
关键词
innate immune response; Nod-like receptor (NLR); pathogen recognition; retinoic acid-inducible gene-I receptor (RIG-I-like receptor, RLR); Toll-like receptor (TLR)
资金
- Japan Society for the Promotion of Science [P08123]
Immunity against microbial pathogens primarily depends on the recognition of pathogen components by innate receptors expressed on immune and non-immune cells. Innate receptors are evolutionarily conserved germ-line-encoded proteins and include TLRs (Toll-like receptors), RLRs [RIG-I (retinoic acid-inducible gene-I)-like receptors] and NLRs (Nod-like receptors). These receptors recognize pathogens or pathogen-derived products in different cellular compartments, such as the plasma membrane, the endosomes or the cytoplasm, and induce the expression of cytokines, chemokines and co-stimulatory molecules to eliminate pathogens and instruct pathogen-specific adaptive immune responses. In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据