期刊
BIOLOGICAL PSYCHIATRY
卷 49, 期 10, 页码 848-860出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)01051-9
关键词
schizophrenia; epilepsy; P300; N1; psychosis
资金
- NCRR NIH HHS [MO1-RR00070] Funding Source: Medline
- NIMH NIH HHS [MH58262, MH53485, MH40052, MH58007] Funding Source: Medline
Background: The scalp-recorded N1 and P300 components of the event-related brain potential (ERP) are commonly reduced in patients with schizophrenia but not in patients with epilepsy. Epilepsy patients with interictal chronic schizophrenialike features (EPI-SZ) provide a comparison group for determining whether the ERP amplitude abnormalities seen in schizophrenic patients nl E associated with shared clinical features of EPI-SZ and schizophrenic patients or overlapping pathophysiologies, or are specific to a distinct schizophrenia etiology. Methods: Patients with schizophrenia (n = 24) were compared with normal control subjects (n = 32) and patients with epilepsy syndromes on visual and auditory oddball ERP paradigms. Epilepsy patients included those with chronic interictal schizophrenialike features (n = 6) and those without (n = 16). Results: Auditory P300 amplitude was reduced in both schizophrenic and EPI-SZ patients, whose positive or negative symptoms did not differ. In contrast, N1 amplitude was reduced only in schizophrenic patients. Delays in both N1 and P300 were associated with epilepsy patients and EPI-SZ but not schizophrenic patients. Conclusions: The schizophrenialike symptoms in epilepsy probably represent a phenocopy of schizophrenia with common clinical features and some common pathophysiologies but distinct etiologies, P300 amplitude appears to be sensitive to schizophrenialike features, regardless of whether they occur in the context of schizophrenia ol epilepsy. N1 amplitude reduction appears to be specific to schizophrenia, suggesting its sensitivity to the distinct etiology of schizophrenia.
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