期刊
BIOCHEMICAL JOURNAL
卷 417, 期 -, 页码 411-421出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20081610
关键词
N-myc downstream regulated gene-1 (NDRG-1); oncogenesis; phosphatase and tensin homologue deleted on chromosome 10 (PTEN); phosphoinositide 3-kinase/protein kinase B (PI3K/Akt); transforming growth factor-beta (TGF-beta); tumour suppression
资金
- National Health and Medical Research Council of Australia
- Australian Research Council for a Discovery Grant
- Australian Rotary Health Research Fund
- Cancer Institute of New South Wales for Ph.D. Scholarships
A key to the development of improved pharmacological treatment strategies for cancer is tin understanding of the integration of biochemical pathways involved in both tumorigenesis and cancer suppression. Furthermore, genetic markers that may predict the outcome of targeted pharmacological intervention in an individual are central to patient-focused treatment regimens rather (than file traditional 'one size fits all' approach. Prostate cancer is a highly heterogenous disease in which a patient-tailored care program is a holy grail. This review will describe the evidence that demonstrates the integration of three established pathways: the tumour-suppressive TGF-beta (transforming growth facti pathway, the tumorigenic PI3K/Akt (phosphoinositide 3-kinase/protein kinase B) pathway and the tumour-suppressive PTEN (phosphatase and tensin homologue deleted oil chromosome 10) pathway. It will discuss gene polymorphisms and somatic mutations in relevant genes and highlight novel pharmaceutical agents that target key points in these integrated pathways.
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