期刊
ANNALS OF INTERNAL MEDICINE
卷 134, 期 10, 页码 963-967出版社
AMER COLL PHYSICIANS
DOI: 10.7326/0003-4819-134-10-200105150-00010
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Background: Interferon therapy decreases the incidence of hepatocellular carcinoma in patients with chronic hepatitis C. Objective: To evaluate effects of interferon-alpha on recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. Design: Randomized. controlled trial. Setting: University hospital, medical center, and affiliated hospital in Osaka, Japan. Patients: 30 men were randomly allocated after resection to the interferon-alpha group (n = 15) or the control group (n = 15). Intervention: Patients in the interferon-alpha group received interferon-alpha, 6 MIU intramuscularly daily for 2 weeks, then three times weekly for 14 weeks, and finally twice weekly for 88 weeks. Measurements: Recurrence rates after resection. Results: Recurrent tumors were detected in 5 patients in the interferon-alpha group and in 12 control patients. The recurrence rate was significantly lower in the interferon-alpha group than in the control group (P = 0.037). Conclusion: Postoperative interferon-alpha therapy appears to decrease recurrence after resection of hepatitis C virus-related hepatocellular carcinoma.
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