期刊
BIOCHEMICAL JOURNAL
卷 423, 期 -, 页码 315-321出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20091170
关键词
cancer; cytokine; inflammation; isothiocyanate (ITC); macrophage migration inhibitory factor (MIF); tautomerase
资金
- National Institutes of Health [R01AT004323, R01 CA113899]
- American Cancer Center [IRG81-001-23]
Dietary ITCs (isothiocyanates) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified MIF (macrophage migration inhibitory factor) as the principal target of nutrient ITCs in intact cells. ITCs covalently modify the N-terminal proline residue of MIF and extinguish its catalytic tautomerase activity. MIF deficiency does not prevent induction of Phase 2 gene expression, a hallmark of many cancer chemopreventives, including ITCs. Due to the emerging role of MIF in the control of malignant cell growth and its clear involvement in inflammation, inhibition of MIF by nutrient ITCs suggests therapeutic strategies for inflammatory diseases and cancer.
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