期刊
BIOCHEMICAL JOURNAL
卷 420, 期 -, 页码 277-281出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20082421
关键词
atherosclerosis; hydrogen sulfide (H2S); low-densitylipoprotein (LDL) oxidation; lipid hydroperoxide; (9-S)-hydroxy-(10E,12Z)-octadecadienoic acid (9-HODE); (9S)-hydroperoxy-(10E,12Z)-octadecadienoic acid (9-HPODE)
资金
- Oesterreichische National bank Jubilaumsfonds [10537]
LOOHs (lipid hydroperoxides) in oxLDL oxidized LDL (low-density lipoprotein) are potentially atherogenic compounds. Recently, H2S was identified as the third endogenous gasotransmitter in the vasculature. H2O2 is known to be destroyed by H2S. Assuming that H2S may also react with LOOHs, the results show that H2S can destroy LOOHs in oxLDL. The ability of LOOH-enriched LDL to induce HO-1 (haem oxygenase 1) in endothelial cells was abolished by 1-I,S pretreatment. I-IPLC analysis showed that 9-HPODE [(9S)-hydroperoxy-(10E,12Z)octadecadienoic acid], a compound found in oxLDL, was reduced to 9-HODS [(9S)-hydroxy-(10E,12Z)-octadecadienoic acid] in the presence of H2S. Thus H2S may act its an antiatherogenic agent by reducing LOOHS to the less reactive LOHs and could abrogate the pathobiological activity of oxLDL.
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