期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 48, 期 1, 页码 43-65出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-409X(01)00101-6
关键词
pharmaceutical analysis; polymorphism; solid-state spectroscopy; IR; Raman; solid-state NMR
The physical characterization of pharmaceutical solids is an integral aspect of the drug development process. This review summarizes the use of solid-stare spectroscopy techniques used in the physical characterization of the active pharmaceutical ingredient, excipients, physical mixtures, and the final dosage form. A brief introduction to infrared, Raman, and solid-state NMR experimental techniques are described as well as a more thorough description of qualitative and quantitative applications. The use of solid-state imaging techniques such as IR, Raman, and TOF-SIMS is also introduced to the reader. (C) 2001 Elsevier Science B.V. All rights reserved.
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