期刊
BIOCHEMICAL JOURNAL
卷 410, 期 -, 页码 1-17出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20071427
关键词
hVps34; hVps15; phosphoinositide; phosphoinositide 3-kinase (PI3K); target of rapamycin (TOR); vacuolar protein sorting 34 (Vps34)
资金
- NIDDK NIH HHS [R01-DK070679] Funding Source: Medline
- NIGMS NIH HHS [R01-GM55692] Funding Source: Medline
The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and is the sole PI3K in yeast. The homologue in mammalian cells, hVps34, has been studied extensively in the context of endocytic sorting. However, hVps34 also plays an important role in the ability of cells to respond to changes in nutrient conditions. Recent studies have shown that mammalian hVps34 is required for the activation of the mTOR (mammalian target of rapamycin)/S6K1 (S6 kinase 1) pathway, which regulates protein synthesis in response to nutrient availability. In both yeast and mammalian cells, Class III PI3Ks are also required for the induction of autophagy during nutrient deprivation. Finally, mammalian hVps34 is itself regulated by nutrients. Thus Class III PI3Ks are implicated in the regulation of both autophagy and, through the mTOR pathway, protein synthesis, and thus contribute to the integration of cellular responses to changing nutritional status.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据