期刊
BIOCHEMICAL JOURNAL
卷 409, 期 -, 页码 349-355出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20071196
关键词
apoptosis; atherosclerosis; lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1); oxidized low-density lipoprotein (OxLDL); scavenger receptor
资金
- British Heart Foundation [PG/06/141/21879] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Scavenger receptors are membrane glycoproteins that bind diverse ligands including lipid particles, phospholipids, apoptotic cells and pathogens. LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is increasingly linked to atherosclerotic plaque formation. Transgenic mouse models for LOX-1 overexpression or gene knockout suggests that LOX-1 contributes to atherosclerotic plaque formation and progression. LOX1 activation by oxidized LDL (low-density lipoprotein) binding stimulates intracellular signalling, gene expression and production of superoxide radicals. A key question is the role of leucocyte LOX-1 in pro-atherogenic lipid particle trafficking, accumulation and signalling leading to differentiation into foam cells, necrosis and plaque development. LOX-1 expression is elevated within vascular lesions and a serum soluble LOX1 fragment appears diagnostic of patients with acute coronary syndromes. LOX-1 is increasingly viewed as a vascular disease biomarker and a potential therapeutic target in heart attack and stroke prevention.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据