期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 11, 期 10, 页码 1281-1284出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00189-5
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资金
- NCI NIH HHS [CA18119] Funding Source: Medline
- NIDDK NIH HHS [5R37 DK15556] Funding Source: Medline
To prepare novel estrogen receptor (ER) ligands, we have developed a facile approach to substituted hexahydrochrysene and tetrahydrobenzo[a]fluorene systems. Substituents, including basic side chains, were added to these systems, and their binding affinity to ER alpha and ER beta, and in some cases their transcriptional activity were evaluated. (C) 2001 Elsevier Science Ltd. All rights reserved.
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