One-pot synthesis of N-trimethylsilyloxy-α-amino phosphonates from aldehydes using lithium perchlorate/diethyl ether as a catalyst

A simple and efficient one-pot method was developed to give N-trimethylsilyloxy-alpha -amino phosphonate derivatives from aldehydes+hydroxylamines+dimethyl(trimethylsily)phosphonate in lithium perchlorate/diethyl either solution (LPDE) in high yields. (C) 2001 Elsevier Science Ltd. All rights reserved.