期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 309, 期 1, 页码 121-138出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/jmbi.2001.4652
关键词
RegB/RegA; global gene regulation; photosynthesis; respiration; cytochromes
资金
- NIGMS NIH HHS [GM53940, R01 GM038237, GM38237, R37 GM040941, R01 GM040941] Funding Source: Medline
Recently, we demonstrated that the RegB/RegA two-component regulatory system from Rhodobacter capsulatus functions as a global regulator of metabolic processes that either generate or consume reducing equivalents. For example, the RegB/RegA system controls expression of such energy generating processes as photosynthesis and hydrogen utilization. In addition, RegB/RegA also control nitrogen and carbon fixation pathways that utilize reducing equivalents. Here, we use a combination of DNase I protection and plasmid-based reporter expression studies to demonstrate that RegA directly controls synthesis of cytochrome cbb(3) and ubiquinol oxidases that function as terminal electron accepters in a branched respiratory chain. We also demonstrate that RegA controls expression of cytochromes c(2), c(y), and the cytochrome be, complex that are involved in both photosynthetic and respiratory electron transfer events. These data provide evidence that the RegB/RegA two-component system has a major role in controlling the synthesis of numerous processes that affect reducing equivalents in Rhodobacter capsulatus. (C) 2001 Academic Press.
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