期刊
NEUROREPORT
卷 12, 期 7, 页码 1421-1425出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200105250-00025
关键词
acidosis; carotid body; chemotransduction; hypoxia; membrane potential; Na+ conductance; patch-clamp; type I cell
Substitution of extracellular Na+ with N-methyl D-glucamine caused marked hyperpolarisation in rat isolated carotid body type I cells,suggesting the presence of a standing Na+ conductance. Choline substitution produced smaller hyperpolarisations, whilst Li+ was virtually without effect. This Na+ conductance was not blocked by amiloride, tetrodotoxin, Zn2+ or Gd3+ and did not arise from electrogenic Na-glucose cotransport, since substitution of glucose with sucrose could not mimic the effects of Naf substitution. Hypoxia and acidosis did not modify the tonic Na+ influx. Our results suggest that Na+ influx provides a constant depolarising influence on type I cells which acts to shift membrane potential beyond that required for initiation of neurosecretion, an essential step in carotid body chemotransduction. NeuroReport 12:1421-1425 (C) 2001 Lippincott Williams & Wilkins.
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