期刊
ONCOGENE
卷 20, 期 24, 页码 3166-3173出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204340
关键词
DNA methylation; MeCP2; Rett syndrome; histone deacetylase; chromatin
资金
- NICHD NIH HHS [1K22 HD01238-01] Funding Source: Medline
A correlation between DNA methylation and transcriptional silencing has existed for many Sears. Recently, substantial progress has been reported in the search for proteins that interpret the regulatory information inherent in DNA methylation and translate this information into functional states, resulting in the identification of a family of highly conserved proteins, the MBD family. Direct connections between these proteins and histone modification enzymes have emerged as a common theme, implying that DNA methylation exerts its effects primarily through repressive chromatin architecture. Recent structural determinations of the DNA binding domain of two MBD family members, MeCP2 and MBD1, provide a framework to model the interactions of this family with DNA, Comparative sequence analysis and experimental DNA binding data can be interpreted using this structural framework allowing one to contrast the members of the MBD family with each other and to predict the properties of new family members. The identification of mutations in MeCP2, the founding member of this family, as causal for the neurological developmental disorder Rett Syndrome provides additional information regarding amino acid residues crucial to the functions of this interesting protein family.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据