Synthesis of N-arylated oxazolidinones via a palladium catalyzed cross coupling reaction.: Application to the synthesis of the antibacterial agent Dup-721

A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-721 are described. (C) 2001 Elsevier Science Ltd. All rights reserved.