期刊
SCIENCE
卷 292, 期 5522, 页码 1728-1731出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.292.5522.1728
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资金
- NIDDK NIH HHS [R01 DK56886, R01 DK040936, P30 DK50306] Funding Source: Medline
- NIGMS NIH HHS [GM07229] Funding Source: Medline
- PHS HHS [P30 19525] Funding Source: Medline
Glucose homeostasis depends on insulin responsiveness in target tissues, most importantly, muscle and Liver. The critical initial steps in insulin action include phosphorylation of scaffolding proteins and activation of phosphatidylinositol 3-kinase. These early events Lead to activation of the serine-threonine protein kinase Akt, also known as protein kinase B. We show that mice deficient in Akt2 are impaired in the ability of insulin to Lower blood glucose because of defects in the action of the hormone on Liver and skeletal muscle. These data establish Akt2 as an essential gene in the maintenance of normal glucose homeostasis.
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