A combined artificial neural network modeling-particle swarm optimization strategy for improved production of marine bacterial lipopeptide from food waste

In the present study, an artificial neural network (ANN) modeling coupled with particle swarm optimization (PSO) algorithm was used to optimize the process variables for enhanced lipopeptide production by marine Bacillus megaterium, using food waste. In the non-linear ANN model, temperature, pH, agitation and aeration were used as input variables and lipopeptide concentration as the output variable. Further, on application of PSO to the ANN model, the optimum values of the process parameters were as follows: pH = 6.7, temperature = 33.3 degrees C, agitation rate = 458 rpm and aeration rate = 128 L h(-1). Significant enhancement of lipopeptide production from waste by about 46% (w/v) with 20 times reduction in operating cost compared to the conventional synthetic medium was achieved under optimum conditions. Thus, the novelty of the work lies in the application of combination of ANN-PSO as optimization strategy to enhance the yield of a fermentative product like lipopeptide biosurfactant from waste. (C) 2014 Elsevier B.V. All rights reserved.