期刊
BIOMETRICS
卷 57, 期 2, 页码 625-631出版社
INTERNATIONAL BIOMETRIC SOC
DOI: 10.1111/j.0006-341X.2001.00625.x
关键词
interim power analysis; sample-size modification; Stein's procedure
资金
- NCI NIH HHS [P01 CA47 982-04] Funding Source: Medline
- NIEHS NIH HHS [5-T32-ES07018] Funding Source: Medline
To compensate for a power analysis based on a poor estimate of variance, internal pilot designs use some fraction of the planned observations to reestimate error variance and modify the final sample size. Ignoring the randomness of the final sample size may bias the final variance estimate and inflate test size. We propose and evaluate three different tests that control test size for an internal pilot in a general linear univariate model with fixed predictors and Gaussian errors. Test 1 uses the first sample plus those observations guaranteed to be collected in the second sample for the final variance estimate. Test 2 depends mostly on the second sample for the final variance estimate. Test 3 uses the unadjusted variance estimate and modifies the critical value to bound test size. We also examine three sample-size modification rules. Only test 2 can control conditional test sire. align with a modification rule, and provide simple power calculations. We recommend it if the minimum second (incremental) sample is at least moderate (perhaps 20). Otherwise, the bounding test appears to have the highest power in small samples. Reanalyzing published data highlights some advantages and disadvantages of the various tests.
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