期刊
FASEB JOURNAL
卷 15, 期 8, 页码 1398-1403出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.00-0833hyp
关键词
necrotizing enterocolitis; prematurity; intestinal inflammation
资金
- NICHD NIH HHS [R37-HD12437, R01-HD31852] Funding Source: Medline
- NIDDK NIH HHS [P01-DK33506] Funding Source: Medline
Neonatal necrotizing enterocolitis (NEC) is a major cause of morbidity in preterm infants. We hypothesize that the intestinal injury in this disease is a consequence of synergy among three of the major risk factors for NEC: prematurity, enteral feeding, and bacterial colonization. Together these factors result in an exaggerated inflammatory response, leading to ischemic bowel necrosis. Human milk may decrease the incidence of NEC by decreasing pathogenic bacterial colonization, promoting growth of nonpathogenic flora, promoting maturation of the intestinal barrier, and ameliorating the proinflammatory response.
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