期刊
MAGNETIC RESONANCE IN MEDICINE
卷 45, 期 6, 页码 1126-1129出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.1149
关键词
diffusion; tensor; brain; MRI
资金
- NCRR NIH HHS [1P41RR09784] Funding Source: Medline
- NINDS NIH HHS [1R01NS35959] Funding Source: Medline
The diffusion time dependence of the brain water diffusion tenser provides information regarding diffusion restriction and hindrance but has received little attention, primarily due to limitations in gradient amplitude available on clinical MRI systems, required to achieve short diffusion times, Using new, more powerful gradient hardware, the diffusion time dependence of tenser-derived metrics were studied in human brain in the range 8-80 ms, which encompasses the shortest diffusion times studied to date. There was no evidence for a change in mean diffusivity, fractional anisotropy, or in the eigenvalues with diffusion time in healthy human brain. The findings are consistent with a model of unrestricted, but hindered water diffusion with semipermeable membranes, likely originating from the extracellular space in which the average extracellular separation is less than 7 microns. Similar findings in two multiple sclerosis plaques indicated that the sire of the water diffusion space in the lesion did not exceed this dimension, (C) 2001 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据