期刊
JOURNAL OF VIROLOGY
卷 75, 期 11, 页码 5363-5369出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.11.5363-5369.2001
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资金
- NIAID NIH HHS [F32 AI009607, R01 AI023173, AI-23173, F32 AI-09607] Funding Source: Medline
The Fusion (F) protein of the paramxyovirus simian parainfluenza virus 5 (SV5) promotes virus-cell and cell-cell membrane fusion, Previous work had indicated that removal of the SV5 F protein cytoplasmic tail (F Tail- or F Delta 19) caused a block in fusion promotion at the hemifusion stage. Further examination has shown that although the F Tail- mutant is severely debilitated in promotion of fusion as measured by using two reporter gene assays and is debilitated in the formation of syncytia relative to the wild-type F protein, the F Tail- mutant is capable of promoting the transfer of small aqueous dyes. These data indicate that F Tail- is Fully capable of promoting formation of small fusion pores. However, enlargement of fusion pores is debilitated, suggesting that either the cytoplasmic tail of the F protein plays a direct role in pore expansion or that it interacts with other components which control pore growth.
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