期刊
NEUROPSYCHOPHARMACOLOGY
卷 24, 期 6, 页码 706-709出版社
SPRINGERNATURE
DOI: 10.1016/S0893-133X(00)00251-7
关键词
anorexia nervosa; bulimia nervosa; recovery; galanin; GABA
Galanin (GAL) and gamma amino butyric acid (GABA) are orexigenic neuropeptides that could contribute to the pathogenesis of anorexia nervosa (AN). To avoid the confounding effects of the ill state, we studied women who were recovered (> 1 year, normal weight, and regular menstrual cycles, no bingeing or purging) from AN (REC AN) and matched healthy control women (NC). CSF GAL was reduced in REC AN (64.4 +/- 8.6 pg/ml) compared to NC (72.0 +/- 11.6 pg/ml; p < .05), GABA was similar between groups. In the brain, GAL stimulates appetite and fat consumption. These data raise the question of whether alterations in brain GAL activity plays a role in clinical symptoms in AN, such as food restriction and fat avoidance. (C) 2001 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.
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