期刊
DIAGNOSTIC MOLECULAR PATHOLOGY
卷 10, 期 2, 页码 69-77出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00019606-200106000-00001
关键词
non-Hodgkin's lymphoma; antigenic receptor genes; aberrant rearrangements; proliferation; polymerase chain reaction; PCR
The current study analyzes the rearrangement pattern of immunoglobulin H (IgH), T-cell receptor (TCR)-gamma, and TCR-beta genes in a group of 80 non-Hodgkin's lymphomas (NHL) of different histologic subtypes (43 B-cell and 37 T-cell types). The sensitivity and specificity provided by polymerase chain reaction amplification of these loci are evaluated. The association between the proliferation index and the presence of the so-called aberrant or dual rearrangements is also considered. Ninety-one percent of B-celI NHL showed IgH gene monoclonality, and 21% also exhibited a monoclonal pattern in one of the TCR genes. Among T-cell NHL, the sensitivity of the study was 65% for the TCR-gamma gene and 46% for the TCR-P gene. The total sensitivity was 76%, amplifying both loci. IgH gene aberrant rearrangements were observed in 16% of T-cell neoplasms. A substantial percentage of dual rearrangements were detected in precursor and mature B- and T-cell NHL. B-cell NHL showed a tendency toward higher values of proliferation when aberrant rearrangements were present; however, this trend was not significant. Furthermore, in the case of T-cell NHL there was a significant negative association between these two variables.
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