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James A. McCormick et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
Akihito Ohta et al.
BIOCHEMICAL JOURNAL (2013)
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation
Guojin Wu et al.
FEBS LETTERS (2013)
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4
Shigeru Shibata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension
Mai Wakabayashi et al.
CELL REPORTS (2013)
Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase
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CELL METABOLISM (2012)
Selective Proteasomal Degradation of the B′β Subunit of Protein Phosphatase 2A by the E3 Ubiquitin Ligase Adaptor Kelch-like 15
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities
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NATURE (2012)
Mechanism of Cullin3 E3 Ubiquitin Ligase Dimerization
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PLOS ONE (2012)
The Cullin-RING E3 Ubiquitin Ligase CRL4-DCAF1 Complex Dimerizes via a Short Helical Region in DCAF1
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BIOCHEMISTRY (2011)
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MOLECULAR CELL (2010)
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NATURE REVIEWS CARDIOLOGY (2010)
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MOLECULAR CELL (2009)
Cullin Mediates Degradation of RhoA through Evolutionarily Conserved BTB Adaptors to Control Actin Cytoskeleton Structure and Cell Movement
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MOLECULAR CELL (2009)
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Jove-Journal of Visualized Experiments (2009)
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EXPERIMENTAL CELL RESEARCH (2008)
G(12)-G(13)-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
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NATURE MEDICINE (2008)
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CELL (2007)
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MOLECULAR CELL (2007)
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CANCER RESEARCH (2007)
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer
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MOLECULAR BIOLOGY OF THE CELL (2007)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
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GENES & DEVELOPMENT (2004)
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
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NATURE (2003)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells
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EMBO REPORTS (2002)
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HYPERTENSION (2001)
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1
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MOLECULAR AND CELLULAR BIOLOGY (2000)
Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)