期刊
NATURE CELL BIOLOGY
卷 3, 期 6, 页码 573-579出版社
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/35078549
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- NCRR NIH HHS [R24 RR012596] Funding Source: Medline
- NIGMS NIH HHS [F32 GM019167-02, F32 GM019167-01, F32 GM019167] Funding Source: Medline
- NIH HHS [R24 OD010943] Funding Source: Medline
In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Epsl5-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-l mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.
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