期刊
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 39, 期 6, 页码 531-546出版社
WILEY
DOI: 10.1002/ajim.1052
关键词
colon neoplasms; case-control study; occupation; occupational exposures; epidemiology
Background We conducted a population-based case-control study in Montreal, Canada, to explore associations between hundreds of occupational circumstances and several cancer sites, including colon. Methods We interviewed 497 male patients with a pathologically confirmed diagnosis of colon cancer, 1514 controls with cancers at other sites, and 533 population-based controls. Detailed job histories and relevant potential confounding variables were obtained, and the job histories were translated by a team of chemists and industrial hygienists into a history of occupational exposures. Results We found that there was reasonable evidence of associations for men employed in nine industry groups (adjusted odds ranging from 1.1 to 1.6 per a 10-year increase in duration of employment), and in 12 job groups (OR varying from 1.1 to 1.7). In addition, we found evidence of increased risks by increasing level of exposures to 21 occupational agents, including polystyrene (OR for substantial exposure (ORsubst)=10.7), polyurethanes (ORsubst=8.4), coke dust (ORsubst=5.6), mineral oils (ORsubst=3.3), polyacrylates (ORsubst=2.8), cellulose nitrate (ORsubst=2.6), alkyds (ORsubst=2.5), inorganic insulation dust (ORsubst=2.3), plastic dusts (ORsubst=2.3), asbestos (ORsubst=2.1), mineral wool fibers (ORsubst=2.1), glass fibers (ORsubst=2.0), iron oxides ORsubst=1.9), aliphatic ketones (ORsubst=1.9), benzene (ORsubst=1.9), xylene (ORsubst=1.9), inorganic acid solutions (ORsubst=1.8), waxes, polishes (ORsubst=1.8), mononuclear aromatic hydrocarbons (ORsubst=1.6), toluene (ORsubst=1.6), and diesel engine emissions (ORsubst=1.5). Not all of these effects are independent because some exposures occurred contemporaneously with others or because they referred to a group of substances. Conclusions We have uncovered a number of occupational associations with colon cancer For most of these agents, there are no published data to support or refute our observations. As there are few accepted risk factors for colon cancel; we suggest that new occupational and toxicologic studies be undertaken focusing on the more prevalent substances reported herein. Am. J. Ind. Med. 39:531-546, 2001. (C) 2001 Wiley-Liss, Inc.
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