期刊
LEUKEMIA & LYMPHOMA
卷 42, 期 1-2, 页码 5-12出版社
HARWOOD ACAD PUBL GMBH
DOI: 10.3109/10428190109097671
关键词
impaired transendothelial migration; B-CLL; L-selectin expression; chronic lymphocytic leukemia
The emigration of lymphocytes from blood into lymph nodes is regulated by the expression of the adhesion molecule, L-selectin on the lymphocyte surface which arrests the rolling of the cell on the vessel wall and allows firmer adhesive interactions to develop. The expression of L-selectin on B-CLL lymphocytes is less than half that on normal lymphocytes and this difference correlates with an impaired capacity of B-CLL lymphocytes to migrate beneath a monolayer of human umbilical vein endothelial cells. Both the B-cell and T-cell lymphocytes from normal subjects and B-CLL patients show down-regulation of L-selectin and CD23 after transendothelial migration. The reduced expression of L-selectin on B-CLL lymphocytes leads to a relative trapping of these cells in the vascular space and is one factor contributing to the elevation of peripheral lymphocyte count.
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