期刊
PARASITE IMMUNOLOGY
卷 23, 期 6, 页码 281-289出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-3024.2001.00384.x
关键词
Schistosoma japonicum; granuloma formation; nitric oxide; nitric oxide synthase
Nitric oxide (NO) plays diverse roles in a variety of pathological processes. We investigated the role of NO in Schistosoma japonicum egg-induced granuloma formation in a mouse hepatic model. Immunohistological analysis revealed that there is the most intense and extensive inducible nitric oxide (iNOS) expression 2 weeks after egg implantation, and thereafter it decreased considerably with time. Treatment with nitric oxide synthase inhibitors, NIL (L-N-6- (iminoethyl)-lysine) or N omega -nitro-L-arginine methyl ester (L-NAME), resulted in two different types of unusual granulomas at 2 weeks. One type showed suppressed fibrosis; while another showed foreign body-type multinuclear cell formation which frequently appeared particularly when 50 mug/ml NIL was given. At 3 weeks following treatment, fibrotic granulomas with scanty peripheral cellularity was obvious. However there were no apparent changes after this period (at 4 weeks). Cytokine analysis in NIL-treated mice showed a significant increase of IL-4 and IL-13 production at 2 weeks. These findings indicated that nitric oxide contributes to granuloma development during the early stages probably through the regulation of Th2 cytokine production.
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