期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 443, 期 3, 页码 802-807出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.12.047
关键词
Liver regeneration; Proliferation; microRNA-21; Phosphatase and tensin homologue deleted on chromosome 10
资金
- Chengdu Academic Achievement and transformation Program [11DXYB361]
- Sichuan Provincial Science and Technology Support Program [2012SZ0017]
- Key Lab of Molecular Research, West China Hospital/West China Medical School of Sichuan University
MicroRNAs (miRNAs) are involved in controlling hepatocyte proliferation during liver regeneration. In this study, we established the miRNAs-expression patterns of primary hepatocytes in vitro under stimulation of epidermal growth factor (EGF), and found that microRNA-21 (miR-21) was appreciably up-regulated and peaked at 12 h. In addition, we further presented evidences indicating that miR-21 promotes primary hepatocyte proliferation through in vitro transfecting with miR-21 mimics or inhibitor. We further demonstrated that phosphatidylinositol 3'-OH kinase (PI3K)/Akt signaling was altered accordingly, it is, by targeting phosphatase and tensin homologue deleted on chromosome 10, PI3K/Akt signaling is activated by miR-21 to accelerate hepatocyte rapid S-phase entry and proliferation in vitro. (C) 2013 Elsevier Inc. All rights reserved.
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