期刊
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
卷 129, 期 2-3, 页码 229-236出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1096-4959(01)00314-1
关键词
IGFBP-1; IGFBP-3; teleost fish; growth; cortisol; diabetes; fasting; stress; biomarker; catabolism
资金
- NIGMS NIH HHS [GM50089] Funding Source: Medline
In fishes as well as in all Vertebrates in which it has been assessed, physiological shifts toward catabolism (e.g. uch as during food deprivation) are consistently associated with elevations in the serum levels of at least one (often two in fishes) IGFBP in the less than or equal to 31-kDa size range. In mammals, 30-kDa IGFBP-1 is strongly up-regulated under catabolic circumstances, and it plays an important physiological role by sequestering IGF peptides to inhibit energy-expensive growth until conditions are more favorable (e.g, with resumed feeding). Similarly in fishes, it has been found that when the less than or equal to 31-kDa IGFBPs are elevated in serum, somatic growth is inhibited, suggesting a similar growth-inhibitory role of these proteins to that of mammalian IGFBP-1. Three different experimentally-induced catabolic states in fishes are compared in this paper: fasting; insulin-dependent diabetes mellitus (IDDM); and stress. A strong relationship between elevated serum cortisol concentrations and the presence of IGFBPs in each case is noted, and the utility of serum IGFBP measurement to serve as an effective indicator (marker) of catabolic condition in fishes is discussed. (C) 2001 Elsevier Science Inc. All rights reserved.
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