期刊
MULTIPLE SCLEROSIS JOURNAL
卷 7, 期 3, 页码 185-188出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/135245850100700309
关键词
immunosuppressive therapy; progressive multiple sclerosis; cyclophosphamide; corticosteroids; immunomodulating therapy
Fourteen consecutive clinically definite relapsing-remitting multiple sclerosis (MS) patients were treated with monthly intravenous cyclophosphamide (CTX) for 6 months. All had experienced severe clinical deterioration during the 12 months prior to treatment with CTX despite treatment with conventional immunomodulating agents and intravenous methylprednisolone. Treatment with CTX led to improvement and neurologic stability within 6 months which was sustained for at least 18 months after the onset of treatment with CTX. Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and ore resistant to conventional therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据