期刊
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
卷 131, 期 6, 页码 544-547出版社
SPRINGER
DOI: 10.1023/A:1012346401315
关键词
T-2 toxin; enzymes of xenobiotic metabolism; nutritional indoles
Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration.
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