Milolides, new briarane diterpenoids from the western pacific octocoral Briareum stechei

Eleven new briarane-type diterpene lactones, designated milolides (1-8, 10-12), together with four known diterpene lactones (9, 13-15), were isolated from the Micronesian octocoral Briareum stechei collected at Yap, Federated States of Micronesia. One aspect of the stereochemistry of one of the known compounds, solenolide C (9), is revised. Structures of the new compounds were determined from spectral data.