期刊
BLOOD
卷 97, 期 11, 页码 3484-3490出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.V97.11.3484
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- NHLBI NIH HHS [HL-63284, HL-36110] Funding Source: Medline
- NIAID NIH HHS [AI-23483] Funding Source: Medline
A population of metachromatic cells with mast cell (MC) and basophil features was identified recently in the peripheral blood of patients with several allergic disorders. This study now shows that these metachromatic cells express on their surface the high-affinity IgE receptor (Fc epsilon RI), CD4, and the chemokine receptors CCR3, CCR5, and CXCR4, but not the T-cell surface protein CD3 and the monocyte/macrophage surface protein CD68. This population of MCs/basophils can be maintained ex vivo for at least 2 weeks, and a comparable population of cells can be generated in vitro from nongranulated hematopoietic CD3(-)/CD4(+)/CD117(-) progenitors. Both populations of MCs/basophils are susceptible to an M-tropic strain of human immunodeficiency virus 1 (HIV-1). Finally, many patients with acquired immunodeficiency syndrome have HIV-1-infected MCs/basophils in their peripheral blood. Although it is well known that HIV-1 can infect CD4(+) T cells and monocytes, this finding is the first example of a human MC or basophil shown to be susceptible to the retrovirus.(Blood. 2001;97:3484-3490) (C) 2001 by The American Society of Hematology.
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