期刊
MAGNETIC RESONANCE IN MEDICINE
卷 45, 期 6, 页码 1021-1029出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.1136
关键词
cerebral blood flow; cerebral blood volume; MR; frequency filtering; transit time
资金
- NCRR NIH HHS [RR03631, RR08079] Funding Source: Medline
- NINDS NIH HHS [NS38295] Funding Source: Medline
Recently, a technique based on arterial spin labeling, called dynamic arterial spin labeling (DASL (Magn Reson Med 1999;41:299-308)), has been introduced to measure simultaneously the transit time of the labeled blood from the labeling plane to the exchange site, the longitudinal relaxation time of the tissue, and the perfusion of the tissue. This technique relies on the measurement of the tissue magnetization response to a time varying labeling function. The analysis of the characteristics of the tissue magnetization response (transit time, filling time constant, and perfusion) allows for quantification of the tissue perfusion and for transit time map computations. In the present work, the DASL scheme is used in conjuction with echo planar imaging at 4.7 T to produce brain maps of perfusion and transit time in the anesthetized rat, under graded hypercapnia. The data obtained show the variation of perfusion and transit time as a function of arterial pCO(2), Based on the data, CO2 reactivity maps are computed. Published 2001 Wiley-Liss, Inc.(dagger).
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