期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 453, 期 3, 页码 473-479出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.09.108
关键词
Membrane traffic; Endocytosis; Transferrin receptor; Clathrin; Arf GTPase-activating protein
资金
- Ministry of Education, Science, Sports, Culture and Technology of Japan
- Astellas Foundation for Research on Metabolic Disorders
- Takeda Science Foundation, Japan
- Grants-in-Aid for Scientific Research [13J05241] Funding Source: KAKEN
Arf GTPase-activating proteins (Arf GAP) play important roles in the formation of the membrane vesicles that traffic between subcellular membranous organelles. The small Arf GTPase-activating protein (SMAP) subfamily of Arf GAPs has two members, SMAP1 and SMAP2, in mammals. The present study investigated whether these two proteins may have an overlapping function in addition to their previously reported distinct functions. Results showed that the presence of either SMAP1 or SMAP2 was sufficient for endocytosis of the transferrin receptor, and that transferrin incorporation was impaired only by the absence of both SMAP1 and SMAP2. This suggests the involvement of both SMAP1 and SMAP2 in transferrin endocytosis. Results also demonstrated a physical association between SMAP1 and SMAP2, which might serve as a basis for a functional interaction, and identified the intramolecular domains responsible for this association. (C) 2014 Elsevier Inc. All rights reserved.
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