期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 452, 期 2, 页码 226-235出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.06.028
关键词
Genomics; Parkinson's disease (PD); Synuclein; Genome wide association studies (GWAS); microRNA (miRNA)
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [25830044, 24111555, 25290019, 25640030]
- Japan Foundation for Neuroscience and Mental Health
- Grants-in-Aid for Scientific Research [24111555, 25830044, 25640030] Funding Source: KAKEN
Research on Parkinson's disease (PD) has made remarkable progress in recent decades, due largely to new genomic technologies, such as high throughput sequencing and microarray analyses. Since the discovery of a linkage of a missense mutation of the alpha-synuclein (alpha s) gene to a rare familial dominant form of PD in 1996, positional cloning and characterization of a number of familial PD risk factors have established a hypothesis that aggregation of alpha S may play a major role in the pathogenesis of PD. Furthermore, dozens of sensitizing alleles related to the disease have been identified by genome wide association studies (GWAS) and meta-GWAS, contributing to a better understanding of the pathological mechanisms of sporadic PD. Thus, the knowledge obtained from the association studies will be valuable for the personal genome of PD. Besides summarizing such progress, this paper focuses on the role of microRNAs in the field of PD research, since microRNAs might be promising as a biomarker and as a therapeutic reagent for PD. We further refer to a recent view that neurodegenerative diseases, including PD, coexist with metabolic disorders and are stimulated by type 11 diabetes, the most common disease among elderly populations. The development of genomic approaches may potentially contribute to therapeutic intervention for PD. (C) 2014 Elsevier Inc. All rights reserved.
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