期刊
MECHANISMS OF DEVELOPMENT
卷 104, 期 1-2, 页码 49-60出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00361-6
关键词
Drosophila heart; tinman; seven-up; Cardioblasts
资金
- NCRR NIH HHS [1 S10 RR0 9145-01] Funding Source: Medline
The Drosophila gene tinman is essential for dorsal vessel (heart) formation and is structurally and functionally conserved in vertebrates. In the mature embryonic dorsal vessel, tinman is expressed in four of the six pairs of cardioblasts in each segment. We provide evidence that seven-lip, which is homologous to the vertebrate COUP-TF transcription factor and is expressed in the non-Tinman-expressing cardioblasts, represses tinman in these cells. Loss of function seven-lip mutations derepress tinman expression in these cardioblasts while ectopic expression of seven-np represses tinman in the cardioblasts that normally express it. These changes are correlated with alterations in the expression of additional molecular markers for each of these two types of cardioblasts, such as the novel T-box-containing gene Tb66F2 and the potassium channel-encoding gene sur. These observations suggest that seven-up has a role in diversifying cardioblast identities within each segment. We also describe the tin,nan cis sequences that mediate tinman repression by seven-hip and examine whether Seven-up can bind these sequences to directly inhibit tinman. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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