期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 449, 期 2, 页码 208-215出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.05.006
关键词
CHAF1A; Colon cancer; Cell proliferation; Survival
资金
- National Natural Science Foundation of China [81172328]
- Important International Cooperation grants from National Natural Science Foundation of China [81220108021]
- Medical Guidance Project of Shanghai Science and Technology Commission [124119a1700]
- Science and Technology Innovation Plan of Shanghai Science and Technology Commission [11431921000]
- Frontier Technology Union Research Project of Shanghai Municipal Hospitals [SHDC12012105]
- Project of Shanghai Industrial Technology Institute [12DZ942500]
- Medical Climbing Project From Songjiang Health Bureau of Shanghai [2011PD03]
Deregulation of chromatin assembly factor 1, p150 subunit A (CHAF1A) has recently been reported to be involved in the development of some cancer types. In this study, we identified that the frequency of positive CHAF1A staining in primary tumor mucosa (45.8%, 93 of 203 samples) was significantly elevated compared to that in paired normal mucosa (18.7%, 38 of 203 samples). The increased expression was strongly associated with cancer stage, tumor invasion, and histological grade. The five-year survival rate of patients with CHAF1A-positive tumors was remarkably lower than that of patients with CHAF1A-negative tumors. Colon cancer cells with CHAF1A knockdown exhibited decreased cell growth index, reduction in colony formation ability, elevated cell apoptosis rate as well as impaired colon tumorigenicity in nude mice. Hence, CHAF1A upregulation functions as a poor prognostic indicator of colon cancer, potentially contributing to its progression by mediating cancer cell proliferation. (C) 2014 Elsevier Inc. All rights reserved.
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