期刊
FERTILITY AND STERILITY
卷 75, 期 6, 页码 1131-1135出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0015-0282(01)01788-5
关键词
in vitro fertilization; polycystic ovary; ovarian hyperstimulation syndrome; low-dose ovarian stimulation
Objective: To study the benefits of a low-dose stimulation (LDS) protocol with purified urinary follicle-stimulating hormone in patients with polycystic ovaries who have presented previously with a very high ovarian response to a standard hMG stimulation. Design: Cohort study. Setting: Fertility center in a university hospital. Patient(s): Sixty-one patients involved in an IVF/ICSI program from January 1995 to December 1996. Intervention(s): The patients were first stimulated with a standard protocol using hMG and presented with a very high ovarian response. These patients were then stimulated a second time using a low-dose protocol. Cryopreserved embryos were transferred in later artificial or natural cycles until to December 1999. Main Outcome Measure(s): Number of gonadotropin ampules; estradiol level on the day of ovulation induction; follicles, oocytes, and cryopreserved zygotes; fertilization, implantation, and pregnancy rates; and number of ovarian hyperstimulation syndromes (OHSS). Result(s): The number of ampules used, the estradiol level reached, and the number of oocytes obtained were significantly lower under the LDS than the standard protocol. High implantation (21.8%) and clinical pregnancy (38.4%) rates were obtained after LDS. The cumulated deliveries per cycle started and per patient were, respectively, 41.6% and 52.5%. Five patients suffered OHSS with the standard protocol, and none with the LDS. Conclusion(s): The LDS protocol offers a safe and efficient treatment for patients who present with echographic polycystic ovaries and are at risk of an excessive ovarian response to standard IVF stimulation protocols. (Fertil Steril(R) 2001;75:1131-5. (C)2001 by American Society for Reproductive Medicine.).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据