期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 451, 期 4, 页码 467-472出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.07.041
关键词
Baicalin; GluR2 subunit; Bax; Bc1-2; Caspase-3; Antidepressant
资金
- Natural Science Foundation of Jiangsu Province of China [BK2011630]
- Fundamental Research Funds for the Central Universities [JKQ2011036, JKZD2013009]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Research Innovation Program Project for Graduate Students in Jiangsu Province [CXZZ13_03]
- National Found for Fostering Talents of Basic Science (NFFTBS) [J1030830]
- National Undergraduate Training Programs for Innovation and Entrepreneurship [G13034]
Changes of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression could impacts the viability of neurons and brain levels of brain-derived neurotrophic factor (BDNF) expression in the key brain structures in the pathophysiology of depressive disorder. In the present study, chronic unpredictable mild stress (CUMS) degraded performance decreased AMPA receptor expression and increased neuron apoptosis. Treatment with baicalin (20, 40 mg/kg) significantly reversed these changes. This study demonstrates that baicalin has potent antidepressant effect, likely through up-regulated the expression of AMPA receptor and suppression neuron apoptosis in CUMS-treated rats. (C) 2014 Published by Elsevier Inc.
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