期刊
JOURNAL OF IMMUNOLOGY
卷 166, 期 11, 页码 6593-6601出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.11.6593
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- NCI NIH HHS [CA42551] Funding Source: Medline
We identified an IL-7R(alpha+)Sca-1(low)c-Kit(low) population in E14 fetal liver, which is the phenotypical analog of common lymphoid progenitors (CLP) in adult bone marrow. After transfer into newborn mice, the IL-7R alpha (+)Sca-1(low)c-Kit(low) population rapidly differentiated into CD45(+)CD4(+)CD3(-) cells, which are candidate cells for initiating lymph node and Peyer's patch formation. In addition, this population also gave rise to B, T, NK, and CD8 alpha (+) and CD8 alpha (-) dendritic cells. The fetal liver precursors expressed a significantly lower level of the myeloid-suppressing transcription factor Pax-5, than adult CLP, and retained differentiation activity for macrophages in vitro. We propose that the transition from fetal liver IL-7R alpha (+)Sca-1(low)Kit(low) cells to adult CLP involves a regulated restriction of their developmental potential, controlled, at least in part, by Pax-5 expression.
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