期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 453, 期 1, 页码 166-171出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.09.073
关键词
BmNPV; Macropinocytosis; Endocytosis; Cholesterol
资金
- National Science Foundation of China [31101766]
- Natural Science Foundation of Jiangsu Province [BK2011525, BK2011526]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20123220120003]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [11KJB180002]
Bombyx mori nucleopolyhedrovirus (BmNPV) is a serious viral pathogen of silkworm, and no drug or specific protection against BmNPV infection is available at present time. Although functions of most BmNPV genes were depicted in recent years, knowledge on the mechanism of BmNPV entry into insect cells is still limited. Here BmNPV cell entry mechanism is investigated by different endocytic inhibitor application and subcellular analysis. Results indicated that BmNPV enters BmN cells by clathrin-independent macropinocytic endocytosis, which is mediated by cholesterol in a dose-dependent manner, and cholesterol replenishment rescued the BmNPV infection partially. (C) 2014 Elsevier Inc. All rights reserved.
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