期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 12, 期 3, 页码 215-223出版社
ACADEMIC PRESS LTD
DOI: 10.1006/scdb.2000.0247
关键词
cell wall; drug resistance; efflux; mycolic acid; outer membrane
资金
- NIAID NIH HHS [AI-09644] Funding Source: Medline
Bacteria, being unicellular, are constantly exposed to toxic compounds in their environment. Gram-negative bacteria and mycobacteria are unusually successful in surviving in the presence of toxic compounds because they combine two mechanisms of resistance. They produce effective permeability barriers, comprising the outer membrane and the mycolate-containing cell wall, on the cell surface. Further, they actively pump out drug molecules that trickle through the barrier, often utilizing multidrug efflux pumps. In Gram-negative bacteria, multidrug pumps of exceptionally wide specificity frequently interact with outer membrane channels and accessory proteins, forming multisubunit complexes that extrude drug molecules directly into the medium, bypassing the outer membrane barrier.
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