期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 58, 期 7, 页码 902-920出版社
SPRINGER BASEL AG
DOI: 10.1007/PL00000910
关键词
enolase; autoimmunity; rheumatic fever; SLE
资金
- NIAID NIH HHS [AI 42827] Funding Source: Medline
Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据