期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 433, 期 3, 页码 338-344出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.03.003
关键词
Glioma; GOLPH3; Migration; Invasion; RhoA
资金
- National Natural Science Foundation of China [81072072, 81272777]
- Natural Science Foundation of Jiangsu Province [BK2011195]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for New Century Excellent Talents in University [NCET-10-0181]
Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. However, the biological significance of GOLPH3 in glioma progression remains largely unknown. In this study, we report, for the first time, that downregulation of GOLPH3 led to clear reductions in glioma cell migration and invasion. In addition, downregulation of GOLPH3 inhibited the expression of the small GTPase RhoA as well as cytoskeletal reorganization, which are both required for glioma cell migration. Furthermore, we found that the observed reductions in glioma cell migration and RhoA level could be rescued by RhoA overexpression. Taken together, these results show that GOLPH3 contributes to the motility of glioma cells by regulating the expression of RhoA. (C) 2013 Elsevier Inc. All rights reserved.
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