期刊
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
卷 53, 期 6, 页码 529-532出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-3083.2001.00917.x
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- NIAID NIH HHS [AI35914] Funding Source: Medline
Interleukin (IL)-12 has dominated the field of cell-mediated immunity since its discovery more than 10 years ago, and clearly plays an essential role in the development of Th1 cells under a variety of conditions. Recent studies now indicate that the importance of IL-12 is not limited to initiating an immune response, but may contribute to maintaining immunity. Thus, Th1 responses rapidly wane in the absence of IL-12, leading to a loss in protective immunity against intracellular pathogens, such as Leishmania and Toxoplasma. Determining how IL-12 maintains Th1 cells, and consequently cell-mediated immunity, will provide new insights useful in controlling the immune response, and may thus influence the design of new vaccines and immunotherapies.
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